| 세션명 | 대학원생 구두발표 (I) |
|---|---|
| 발표장 | 302호 |
| 논문코드 | 1O11-13 |
| 발표일 | 2019-10-10 |
| 발표시간 | 16:40-16:55 |
| 논문제목 | Robust nanoplatform with protein corona shield system for highly efficient targeted drug delivery |
| 발표자 | 오준용 |
| 발표자 소속 | 울산과학기술원 |
| 저자 | 오준용, 유자형† |
| 소속 | 울산과학기술원 |
| 논문초록 | Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents. However, translating nanoparticle-based agents into clinical applications still remains a challenge due to the difficulty in regulating interactions on the interfaces between nanoparticles and biological systems. Here, we present a targeting strategy for nanoparticles incorporated with a supramolecularly pre-coated recombinant fusion protein combines with glutathione-S-transferase. Once thermodynamically stabilized in preferred orientations on the nanoparticles, the adsorbed fusion proteins as a corona minimize interactions with serum proteins to prevent the clearance of nanoparticles by macrophages, while ensuring systematic targeting functions in vitro and in vivo. This study provides insight into the use of the supramolecularly built protein corona shield as a targeting agent through regulating the interfaces between nanoparticles and biological systems. |
THE POLYMER SOCIETY OF KOREA